Stat Up becomes Stat Down), Any 'Stat down' pills you take give you a permanent +0.6 Damage Up (Horse pills +1.2), Most other pills spawn a black heart when used, including R U A Wizard?, Amnesia, Bad Trip, ?? Pressing it again allows you to throw it at enemies. When used, turns every normal enemy in the room into poop! Jun 05, 2008 |. Effects Trinkets Isaac takes a full heart if hurt by Blood Puppy and it drops a full red heart for every 10 enemies it kills. UNLOCK: Unlock this item by defeating Mother in the Corpse II as Lilith. red, drip, Isaac's health is set to 1 and he also gains 9 extra lives, Each time Isaac dies, he will respawn with 1 Health, Has a chance to drop from the Super Pride mini boss, The floating Dead Cat head that follows you will disappear when you are on your last life (Very useful for The Lost), Item Pool: Devil Room, Curse Room, Red Chest, Super Pride Miniboss, * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal, Gives Isaac demon wings and the ability to fly, * devil pool, devil room pool, devil deal, the lost item pool, cross, upside down, red, black. Butt Bombs, Hot Bombs), When used will teleport you to another random room that has not been explored yet, After all the normal rooms have been explored, the hierarchy of rooms chosen is: Boss Room, Super Secret Room, Shop, Item Room, Sacrifice Room, Dice Room, Library, Curse Room, Miniboss, Challenge Room, Bedroom, Arcade, Vault, Secret Room, Devil/Angel Room, I AM ERROR, This ordering means a Devil and I Am Error room can both be forced if all others have been visited, If used in a normal room with enemies it will teleport you out and back into the exact same room, *, golden, yellow, robot, antenna, black, teleport two, teleport 20, Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it, The trail of black powder left on the floor will quickly disappear, meaning you are limited on the size of the pentagram symbol you can create, REPENTANCE - Black Powder's pentagram can now damage flying enemies, When used, applies the charm effect to any enemies in close range and deals 5 damage. +1 flat damage. According to the Bible, "Brimstone", which is possibly the ancient name for sulfur, evokes the acrid odor of volcanic activity. Unlocked from the 'Once more with the feeling!' You must make it back through the path solving a few bomb puzzles while avoiding her, to get back to the regular floor. When an enemy takes damage from an enemy projectile, it will attempt to target the enemy that fired it, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Judas, Item Pool: Item Room, Greed Mode Item Room, Devil Room, Greed Mode Devil Room, Zodiac will give you a random zodiac item effect that changes after every floor, Possible item effects include: Taurus, Aries, Cancer, Leo, Virgo, Libra, Scorpio, Sagittarius, Capricorn, Aquarius, Gemini or Pisces, UNLOCK: Unlock this item by beating Greed Mode with The Lost, Tears now have a random chance to apply a poison effect, dealing damage equal to your tears each tick, for 2 ticks, Isaac now deals poison damage on contact with enemies similar to The Virus item (Damage over time 4 or 6 per tick), Enemies that were poisoned by contact damage have a 20% chance to drop a black sin heart when killed. UNLOCK: Unlock this item by getting all hard mode completion marks for the 17 non-tainted characters, Combine with Knife Piece 2 to create a Knife which can be fired across the room, dealing 25 damage to any enemies it comes into contact with, In the Downpour/Dross II, you will find a white flame somewhere, and a room with a mirror in it. Unlock Method now allows the player to influence the teleport direction (using the direction Isaac is moving upon activating the item), * item room, treasure room, item room pool, blue remote, robot, When used as the Keeper, one coin HP is restored, Has a chance to drop from the Super Lust miniboss fight, Item Pool: Item Room, Super Lust Miniboss, * item room, treasure room, item room pool, the lost item pool, maggy, starting, Will take red hearts first before any other, Eve starts with this item after donating 439 coins to the Greed Donation Machine, UNLOCK: Unlock this item by beating Satan with Eve, Item Pool: Item Room, Curse Room, Demon Beggar, * devil pool, devil room pool, devil deal, the lost item pool, starting, silver, grey, gray, Upon use, this item refreshes the current floor with brand new rooms, monsters and items, as if you had entered a new floor, UNLOCK: Unlock this item by beating Satan with Blue Baby, Item Pool: Item Room, Secret Room, Devil Room, Demon Beggar, * secret room pool, item room, treasure room, item room pool, pill, tablet, drug, white, Using this card will also open a pathway of red rooms back to the regular floor, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Jacob, "May the darkness swallow all around you", When used, grants +1.5 Damage Up, turns your hearts to Bone hearts and the Spirit of the Night effect (Spectral tears and the ability to fly) for the current floor, Also gives the Curse of Darkness effect that can't be removed for the current floor, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Lazarus, Creates a trapdoor to a guaranteed crawl space, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Eden, When used, this copies the effect of the card, pill, rune, soul stone or active item you used most recently, UNLOCK: Unlock this card by defeating Mega Satan as Tainted Eden, Turns all pedestal items in the current room into rotating items, which cycle between the old item and a random new item every second, This allows you to effectively reroll items like with The D6, but choose the old item as well if you want, Tainted Isaac has this effect passively for all items, If you use more than one in the same room, each pedestal item will cycle through +1 random item, Items are chosen from the item pool related to the current item, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Isaac, When used, all enemies in the current room drop half a red heart that will disappear after 2 seconds if not picked up, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Magdalene, When used, this Soul Stone creates Red rooms for every possible exit in the current room, Red outlines of doors appear where this Soul Stone will create exits for, See the Red Key item description for more information about these Red rooms behave, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Cain, Activates the Dark Arts item effect, which turns Isaac into a ghost for a few seconds. achievement (complete a victory lap, defeating the lamb boss), Horf! UNLOCK: Unlock this item by defeating Ultra Greed as Apollyon, At the start of each new hostile room, you have a 20% chance to gain a random charmed familiar which will fight for you, The charmed enemy has its own health bar and will die if it takes enough damage, Charmed enemies persist between each room and floor for as long as they stay alive, Allows you to have more than one charmed familiar at a time if you can keep them alive, * pokemon, phone, black, green, blue, gps, Every time one of your tears hits an enemy, it has a chance to start bleeding, which will cause it to take damage every 5 seconds, The bleed damage dealt by BackStabber is based on how quickly an enemy is moving (faster enemies take more damage), Damaging enemies from behind gives the bleed effect a 100% chance to apply, While an enemy bleeds, they leave behind creep that damages other enemies, The tear that inflicts the bleed effect also deals double damage, *, knife, dagger, red, heart, silver, knife, When used, Sharp Straw will deal damage to all enemies in the room, The damage dealt is equal to Isaac's current tear damage plus 10% of the enemy's max health, Every time this item deals damage, it has a 15% chance to drop 1/2 red hearts, REPENTANCE - Sharp Straw is now only able to generate half red hearts (previously, it generated half soul hearts if the player had no heart containers), A razor blade orbital that deals contact damage and applies the bleeding status effect to enemies and bosses, which will cause them to take damage every 5 seconds, The contact damage dealt by Mom's Razor is based on how quickly an enemy is moving (faster enemies take more damage), Its speed is not affected by the Guardian Angel item, An eye orbital that shoots tears that deal 3.5 damage and deals 2 contact damage per tick to enemies, The damage dealt by this orbital does not scale with damage upgrades, REPENTANCE - Bloodshot Eye now blocks enemy shots, has increased shot speed and rate of fire, and now only shoots when lined up with enemies, When used, spawns a charmed random white delirium version of a boss, that will fight for you and kill other enemies for the rest of the current room, Possible bosses spawned include most bosses in the game, Some bosses' effects can harm Isaac. UNLOCK: Unlock this item by defeating Delirium in The Void floor with Isaac, A one time use active item that when used, will spawn 2 random item pedestals from the item pool associated with the current room (e.g. Tainted Eve is unlocked by reaching Home and using the Red Key, Cracked Key, or Soul of Cain to access a special room in one of the walls while playing as Eve. After killing a 15 enemies, Blood Puppy transforms into an aggressive version that will also attack Isaac by charging at him. UNLOCK: Unlock this item by defeating challenge #36 (Scat Man), When used, places a sword directly above Isaac's head and while active, will spawn an extra item for every item pedestal spawned, After getting hit once with the item activated, at any time without warning, the sword may fall, instantly killing Isaac regardless of his health, After being hit the sword has a 1/10000 chance every 4 frames to fall. No longer has an "on hit" effect, UNLOCK: Unlock this item by donating 999 pennies to the Shop, * shop room pool, shop item pool, stopwatch, blue, pocket, clock, Tears now revolve around Isaac's Body at a fixed distance until they hit the ground, Aiming in the opposite direction is often better due to how the tears circle around Isaac, Causes a lot of great synergies with items such as Lump of Coal, Brimstone, Rubber Cement, Technology and most of the worm trinkets, REPENTANCE - Tiny Planet's orbit now more tightly follows Isaac. The resulting amount is rounded, and is capped at 29. The beam is piercing and spectral, dealing damage to all enemies and ignoring all obstacles in its path. Chapters All floors guaranteed to have an Arcade except the Chest & Dark Room floors, Judas - Gives a passive Book of Belial item similar to Book of Virtues. Rarer clots have unique effects on tearsBone Clot tears have Compound Fracture, Gold Clots have Midas Touch, Eternal Hearts have Sacred Heart, and Black Hearts have Dark Matter. Every so often it will come up and attempt to grab onto a random enemy in the room, holding them in place and dealing damage, The Worm Friend deals 4 damage for 8 ticks total, If the enemy moves quickly enough it can miss its attack, UNLOCK: Unlock this item by defeating The Beast as Apollyon, Enemies that die will leave behind 1-2 floating bone shards where they die, until you leave the room, Other enemies that touch the bone shards will take 3.5 damage, with a chance to either bounce off them or cause it to break and disappear, UNLOCK: Unlock this item by defeating Mother as The Forgotten, Each time an enemy dies, a friendly red soul appears. Items: Rocket in a Jar, Goat Head, Dead Cat, Soy Milk, Blood Clot. Items This item has two styles, named "Hat" and "No Hat".The "Hat" style retains the default headgear, while the "No Hat" style hides it.. The damage done by Glass Cannon is calculated as follows: dmg = (dmg * 10) + 10 (i.e. - Turns Isaac invincible for a few seconds (similar to Unicorn Stump). Endings. Activating Sumptorium restores Tainted Eve's health (if possible) and axes living clots (though not all of them? Magdalene . Endings. No wind could lift those waves, grey metal, poisonous foggy waters. 4 keys = 50% chance. However after the first damage tick, there is an additional pause for ~0.12 seconds (7 frames). 5.100.229 Rooms blue, white, triangle, Isaac's tears become large, brown and will penetrate all objects and enemies (piercing + spectral), Despite the increase in tear size, Dead Onion does NOT increase your damage stat. treasure room, item room pool, yellow, golden, ring, circle, Item Pool: Item Room, Shop, Challenge Room, Beggar, Demon Beggar, Mom's Chest, * dungeon room, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool, item room, treasure room, item room pool, yellow, red, blue, medicine, jar, drug, moms bottle of pills, Tears now have a random chance to apply a poison effect, causing double your tear damage per tick to enemies over time, The chance to fire poison shots is affected by your luck stat and at +12 Luck it will activate every time, * item room, treasure room, item room pool, green, snot, booger, ball, slime, Isaac's tears now split into two upon contact with enemies or the environment, Tears that split off from the main tear do less damage (tear damage * 0.5), Tears can keep splitting if they still have range and damage above 1, UNLOCK: Unlock this item by collecting two of the following items: Bob's Rotten Head, Dead Cat, Cricket's Head, Tammy's Head, * item room, treasure room, item room pool, pink, slug, bug, face, When used, replaces all pedestal items in the current room with another random item. If a devil deal was already taken this run, it spawns 2 soul hearts and 1 Angel Room item instead. ( : Stigmata Speed Ball Chemical Peel Bloody Lust Cat-O-Nine-Tails Stem Cells Tooth Picks SMB Super Fan! Once you've beaten Mother once, a door will appear at the starting room in Depths II, which leads to the Mausoleum/Gehenna floors. Can fire tears but is immune to damage, Tainted Eden - Items taken before Birthright no longer get rerolled when taking damage, Tainted Lost - Grants an extra life. *, blue, baby, grow, headless, golden chest pool, gold chest pool, Isaac's tears become coins and now have a 5% chance to drop pennies on the floor upon successfully hitting an enemy, Has a chance to drop when exploding a dead shopkeeper, A familiar blue fly that will follow Isaac's movement pattern but delayed by 1 second, Papa Fly will fire tears at nearby enemies that deal damage equal to Isaac's tear damage, A familiar baby that will follow your movement pattern on a 2 second delay, Tears that pass through the baby will double up and gain x1.33 speed boost, Isaac's normal bombs become pink and causes them to drop random pickups when they explode (e.g. For reference, Rebirth . Spawns coins as The Keeper, I can see forever - Opens secret room and super secret room entrances on the current floor, I found pills - Changes the appearance of Isaac's face for the current room (Cosmetic change only), Lemon Party - Spawns a large yellow pool on the floor around you, damaging enemies which walk in it, Paralysis - Prevents you from moving for a short while, Pheromones - Applies the charm effect to all enemies in the room for a short while, Puberty - Causes Isaac to grow hair for the rest of the run. If the player has all mapping effects, it grants the "I can see forever!" Takes more shots before breaking, Bomb poop - Throws a butt bomb that explodes after 2 seconds, UNLOCK: Unlock this item by defeating Delirium as Tainted Blue Baby, Allows you to quickly double tap a shoot button to sneeze on nearby enemies, dealing x1.5 your tear damage and pushing them back slightly, If an enemy is pushed into a wall or object it takes 10 damage, UNLOCK: Unlock this item by defeating Delirium as Tainted Azazel, Bombs become spectral and can now pass through objects, Bombs spawn a friendly white soul, which will hunt down other enemies, dealing contact damage which scales with your tear damage, After 10 seconds the white soul explodes dealing 7 damage to nearby enemies. the lost item pool, white, blue, cross, jar, Gives Isaac an eternal heart and the ability to fly, UNLOCK: Unlock this item by beating the Chest with Blue Baby, * golden chest pool, gold chest pool, blue head, the lost item pool, dead, ball, Upon taking damage, Isaac will fart a few times, causing all enemies in close proximity to become poisoned and leaving a gas cloud behind, Black Bean deals your tear damage for 6 ticks, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, treasure room, item room pool, the lost item pool, kidney, grey, gray, Allows Isaac to fly while the White Pony is held, While held, sets your speed stat to 1.5 if it isn't already that high. Replacing all 12 containers with broken hearts will kill you instantly. ItemID: 254 "DMG + range up" +1.0 Damage Up (Left eye only). UNLOCK: Unlock this item by defeating Mother in the Corpse II as Lilith, Item Pool: Item Room, Red Chest, Curse Room, During the transition between floors, this item shows you a preview of the item that will spawn in the item room, and the boss that will appear, This effect will work even if you have Curse of the Blind, but the item will still appear as a ? Only contact poison has this effect - poison from tears doesn't work, UNLOCK: Unlock this item by beating Satan with Lilith, *, green, lips, kiss, drip, drop, serpents kiss, serpent kiss, Isaac will now fire tears automatically directed at a red target on the ground which is controlled by the player, This allows for a full 360 degree tear firing radius, Can be overridden by other tear modifiers such as Mom's Knife or Brimstone, Every time you leave the room this effect turns off until you press a shoot button again, Tears are replaced with the ability to charge and fire a laser ring that travels across the room, The size of the ring will depend on how long you charge it, The laser ring does damage scaling based on charge, from 25% at minimum to 100% at max, Rings have infinite range and travel until they hit a wall, Multiple Tech X stacks - every one taken adds another laser ring (doesn't affect your fire rate), * tech 10, tech ten, donut laser rings, vr, headset, visor, Allows you to create one brown tunnel and one blue tunnel in the floor, that can be used to teleport between wherever you placed each one, This item will let you port out of the devil room but not back into it, Very useful in the boss rush and challenge rooms, *, scalpel, red, silver, white, grey, gray, metal, knife, cut, Isaac's tears now travel directly forwards following a beam of light, but will also move sideways based on your player movement, Allows for more accurate correction when firing tears, as their direction can be controlled even after they have been fired, If you switch the direction in which you are firing tears, the beam of light and all your tears will also be transported to the new direction, Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size for 5 seconds and also run away from Isaac, Shrunk enemies can be crushed and killed by walking over them, After firing tears for 3 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring which deals a lot of damage to any enemies inside it, The ring deals damage equal to your tear damage rapidly to any enemies in contact with it, for a total of 30 ticks of damage, You have to keep the fire button held down for the full 3 seconds to cause this effect, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Azazel, In addition to tears, Isaac now holds a spear infront of him which deals damage equal to 2 times your tear damage. It can only be fired after a short charge-up . ( : Guppy's Tail Mom's Purse Bob's Curse Pageant Boy Scapular Infestation The Mulligan Habit Spirit Of The Night Ankh Celtic Cross Mitre Fate The Black Bean Holy Grail Dead Dove Pyro 3 Dollar Bill Mom's Coin Purse Box), ( : Guppy's Paw IV Bag Best Friend Remote Detonator Guppy's Head Prayer Card Notched Axe Crystal Ball Crack The Sky The Candle D20 Spider Butt Dad's Key Portable Slot White Pony Blood Rights), Books: The Bible The Book of Belial The Necronomicon Book Of Revelations Book of Shadows Anarchist Cookbook The Book Of Sin Monster Manuel While firing tears the water will be fired as a projectile across the room. Type: Passive, Familiar . green, red, bloody, A familiar that follows Isaac and leaves blood creep on the floor as it floats, hurting enemies that walk over it for 2 damage per tick, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, bloody, red, You can pick which dice you want to use. grey, gray, lamp, UNLOCK: Unlock this item by making a Super Bandage Girl, * boss room pool, boss room item, pink, plaster, sticker, item room, treasure room, item room pool, the lost item pool, When used Isaac transforms into pacman, which makes him invincible for 6 seconds and does 40 contact damage to enemies per chomp, Everytime you 'eat' 2 enemies, you regain 1/2 heart of red health, You can't shoot tears while the effect is active, UNLOCK: Unlock this item by visiting 10 arcades, * item room, treasure room, item room pool, gameboy, grey, gray, white, A bag that floats around following Isaac and drops a random coin every 2 rooms, UNLOCK: Unlock this item by beating Isaac with Cain, * secret room pool, item room, treasure room, item room pool, bag, purple, pouch, A familiar which follows Isaac and shoots lasers, similar to the Technology item, Robo-Baby's laser is spectral and piercing (It will pass through rocks and objects in the environment), Robo-Baby's lasers deal 3.5 damage per hit, * item room, treasure room, item room pool, robo baby, robot baby, white, grey, gray, silver, red, A familiar which follows Isaac and drops half a red heart every 3 rooms, UNLOCK: Unlock this item by beating the Caves 30 times and defeating C.H.A.D, * lil chad, little chad, item room, treasure room, item room pool, the lost item pool, red, smile, face, bug, Any pickups are possible from this item, including Bombs, hearts, keys, coins, pills, batteries, tarot cards, runes etc, Doesn't produce microbatteries, only regular sized ones and rarely golden/mega batteries, UNLOCK: Unlock this item by beating each of the Seven Sins once, Item Pool: Item Room, Library, Devil Room, * library pool, library room, book room pool, devil pool, devil room pool, devil deal, item room, treasure room, item room pool, red 7 book, grey, gray, black, A blue cross that follows Isaac and drops a soul heart every 7-8 rooms, REPENTANCE - The Relic now generates soul hearts less frequently, UNLOCK: Unlock this item by beating the Isaac boss with Maggy, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, Done by Glass Cannon is calculated as follows: dmg = ( dmg * )... 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